The following case describes the beneficial effects of riluzole in a patient with obsessive-compulsive disorder (OCD) and major depressive diso. We are using cookies to give you the best experience on our website, but you are free to manage these at any time. This drug, initially approved as a neuroprotective agent for patients with amyotrophic lateral sclerosis, has several actions in the brain that appear to contribute to its antiglutamatergic activity: an inhibitory effect on glutamate release, inactivation of voltage dependent sodium channels in cortical neurons, and blockade of GABA reuptake (Stefani et al. One candidate agent is the antiglutamatergic drug, riluzole (Rilutek). Preclinical and clinical studies suggest that drugs that reduce glutamatergic activity might play a role in the treatment of both mood and obsessive-compulsive disorders (Krystal et al. Altered glutamatergic neurotransmission has been implicated in the pathophysiology of mood and anxiety disorders (Berman et al.
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